ONPATTRO® Infusion Therapy

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About ONPATTRO® Infusion Therapy

ONPATTRO® is a prescription medicaine used to treat adults with polyneuropathy (nerve damage) caused by hereditarty transthyretin-mediated (hATTR) amyloidosis. It belongs to a class of drugs called RNA interference therapy (sometimes called a gene silencer). ONPATTRO® was designated an 'orphan medicine' (a medicine used in rare diseases.

Condition treated by this therapy

Polyneuropathy caused by hereditary transthyretin-mediated hATTR
People with hATTR amyloidosis that have an abnormality in the gene that carries the instruction code for TTR protein

The active substance in ONPATTRO®, pastisiran, is a small interfering RNA' (siRNA), a very short piece of synthetic genetic material of the cell responsible for production of defective transthyretin. This reduces production of defective transthyretin, therby reducing the formation of amyloids and relieving the symptoms of hATTR amyloidosis.

ONPATTRO® Price

The out-of-pocket ONPATTRO® price will vary depending on your insurance coverage. If you have questions about your coverage, contact your insurance provider.

No patient should go without necessary treatment due to financial limitations. If you have questions about financial assistance opportunities, contact a member of our Violet Health team.

What to Expect During ONPATTRO® Infusion Therapy

ONPATTRO® is administered as an intravenous infusion in form of an IV drip. You'll get an ONPATTRO® dose every 3 weeks. The recommended dose is 300 micrograms per kilogram of body weight once every 3 weeks.

Pre-treatment may include medicines that help lower chances of infusion-related reactions such as corcticosteroid medicines, paracetamnol, and medicines known as H1 and H2 blockers before receiving ONPATTRO®.

Your doctor will monitor you for any infusion-related reactions during and after the infusion. If you have any infusion-related reaction, your doctor or nurse may slow down or stop your infusion, and you may need to take other medicines.

ONPATTRO® Side Effects

The most common side effects of ONPATTRO® include:

Respiratory infections (colds, sinus infections, and nasal congestion)
Infusion-related reactions
- Reddening of the face or body (flushing)
- Body aches or pain, including pain in the back, neck or joints.
- Nausea
- Abdominal pain
- Dyspnea
- Headache

Treatment with ONPATTRO® lowers the amount of vitamin A inyour blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor. Low vitamin A levels can affect vision. If you develop problems with your vision (e.g., night blindness) while taking ONPATTRO®, talk to your doctor.

ONPATTRO® Infusion Therapy at Violet Health

Your comfort during ONPATTRO® infusion therapy at Violet Health is our priority. Our ONPATTRO® patients enjoy walk-up parking, complimentary entertainment and snacks, and a team of highly trained providers during each treatment. Plus, Violet Health’s evening and weekend hours and convenient city and rural locations make it easier to schedule your appointments.

Violet Health Infusion Centers provides infusion therapy for patients with rare, chronic, or complex conditions in a comfortable, patient-centered atmosphere.

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Patient Forms

Before you attend your first appointment at Violet Health, please make sure to review the documents below. Please contact us if you have any questions!