GIVLAARI® Infusion Therapy
Our Therapies

GIVLAARI® Infusion Therapy

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About GIVLAARI® Therapy

GIVLAARI® (givosiran) is a prescription medicine used to treat acute hepatic porphyria (AHP) in adults. It is an δ-aminolevulinic acid synthase 1 (ALAS1)-directed small interfering RNA (siRNA) that works by targeting the underlying cause of AHP in the liver.

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Conditions treated by this therapy

GIVLAARI® (givosiran) is FDA-approved for the treatment of acute hepatic porphyria (AHP) in adults. It can be used to treat all four types of AHP:

  • Acute intermittent porphyria (AIP)
  • Variegate porphyria (VP)
  • Hereditary coproporphyria (HCP)
  • ALAD-deficiency porphyria (ADP)
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GIVLAARI® Price

The cost of prescription medications can vary depending on your insurance coverage. If you're concerned about the price of your medication:

  • Contact your insurance provider to understand your coverage
  • Ask your doctor or pharmacist about lower-cost alternatives
  • Check with the drug manufacturer about financial assistance programs
  • Explore patient assistance options if you're uninsured or underinsured

Remember, many resources exist to help patients access necessary medications. Don't hesitate to ask for help if you're struggling with medication costs. No patient should go without necessary treatment due to financial limitations. If you have questions about financial assistance opportunities, contact a member of our Violet Health team.

What to Expect During GIVLAARI® Therapy

GIVLAARI® is given once a month as a subcutaneous injection (under the skin) by a healthcare professional. This means you'll need to visit your healthcare provider's office regularly for treatment. Before your infusion, it is important to drink plenty of water and come to your appointment hydrated.

  1. Your dedicated Infusion nurse will check your vitals and review your medical history to check for improvements or potential side effects of your infusion therapy.
  2. Your nurse will begin your infusion and check in on you periodically during your treatment.
  3. After your infusion, your nurse will monitor you to ensure you do not have any complications or reactions to the infusion therapy.

GIVLAARI® side Effects

Common side effects of GIVLAARI® are:

  • Injection site reactions
    • (redness, pain, itchiness, rash, discoloration, or swelling around the injection site.)
  • Nausea
  • Fatigue
  • Nasopharyngitis
  • Headache
  • Urinary tract infection
  • Upper respiratory tract infection

More serious side effects that include medical attention include:

  • Signs of liver problems
    • (pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin)
  • Signs of kidney problems
    • (bloody urine, decreases urine output, increased thirst, swelling, unusual tiredness)
  • Symptoms of allergic reaction
    • (swelling, difficulty breathing, hives)
  • Signs of pacreatitis
    • (acute upper abdominal pain, elevated pancreatic enzymes)

GIVLAARI® Therapy at Violet Health

Your comfort during GIVLAARI®infusion therapy at Violet Health is our priority. Our patients enjoy walk-up parking, complimentary entertainment and snacks, and a team of highly trained providers during each treatment. Plus, Violet Health’s evening and weekend hours and convenient city and rural locations make it easier to schedule your appointments.

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Violet Health Infusion Centers provides infusion therapy for patients with rare, chronic, or complex conditions in a comfortable, patient-centered atmosphere.

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Helpful Resources

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Helpful Resources

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What is FERAHEME

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Treatment Tips

Patient Forms

Before you attend your first appointment at Violet Health, please make sure to review the documents below. Please contact us if you have any questions!

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1

Patient Consent Form

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HIPAA Privacy Authorization Form

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Notice of Privacy Practices

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Patient Rights and Responsibilities

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Appointment Lateness and Cancelation

Meet our Infusion Specialists

  • Jalal Thwainey M.D.

    Jalal Thwainey M.D.

    Medical Director

  • Randy Josey

    Randy Josey

    Director of Partnerships

For Provider

Simplify patient referrals and offer advanced treatment options with our infusion partnership program.

For Patient

There may be a better way to manage your condition – explore infusion therapy.

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Cutting-edge infusion therapies and injections for patients with complex chronic conditions and rare diseases.

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